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-14% ছাড়
বিস্তারিত
Interaction
Monas OFT has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions. In drug interaction studies, the recommended clinical dose of Monas OFT did not have clinically important effects on the pharmacokinetics of the following drugs: theophylline, prednisone, prednisolone, oral contraceptives (norethindrone 1mg/ethinyl estradiol 35mcg), terfenadine, digoxin, and warfarin. Although additional specific interaction studies were not performed, Monas OFT was used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions. These medications included thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines and decongestants. Phenobarbital, which induces hepatic metabolism, decreased the AUC of Monas OFT approximately 40% following a single 10mg dose of Monas OFT. No dosage adjustment for Monas OFT is recommended. It is reasonable to employ appropriate clinical monitoring when potent cytochrome P450 enzyme inducers, such as phenobarbital or rifampin, are co-administered with Monas OFT.
Contraindications
Montelukast is contraindicated in patients who are hypersensitive to any component of this product.
Side Effects
Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection.
Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders.
Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor.
Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders.
Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor.
Pregnancy & Lactation
Montelukast crosses the placenta following oral dosing in rats and rabbits. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Montelukast should be used during pregnancy only if clearly needed. Because many drugs are excreted in human milk, caution should be exercised when Montelukast is given to a nursing mother.
Precautions & Warnings
Monas OFT is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Patients should be advised to have appropriate rescue medication available. Therapy with Monas OFT can be continued during acute exacerbations of asthma. While the dose of inhaled corticosteroid may be reduced gradually under medical supervision, Monas OFT should not be abruptly substituted for inhaled or oral corticosteroids. Monas OFT should not be used as monotherapy for the treatment and management of exercise induced bronchospasm. Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Monas OFT. Although Monas OFT is effective in improving airway function in asthmatics with documented aspirin sensitivity, it has not been shown to truncate bronchoconstrictor response to aspirin and other non-steroidal anti-inflammatory drugs in aspirin-sensitive asthmatic patients.
Overdose Effects
There were no adverse experiences in the majority of overdosage reports. The most frequently occurring adverse experiences were consistent with the safety profile of Monas OFT and included abdominal pain, somnolence, thirst, headache, vomiting and psychomotor hyperactivity. In the event of overdose, it is reasonable to employ the usual supportive measures; e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.
Therapeutic Class
Leukotriene receptor antagonists
Storage Conditions
Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
Chemical Structure
| Molecular Formula : | C35H36ClNO3S |
| Chemical Structure : |  |
Common Questions about Monas OFT 4 mg Flash Tablet
What is Monas OFT 4 mg Flash Tablet?
Monas OFT 4 mg Flash Tablet is a selective and orally active leukotriene receptor antagonist.
What is Monas OFT 4 mg Flash Tablet used for?
Monas OFT 4 mg Flash Tablet is commonly used to treat asthma or allergic rhinitis. It helps keep airways open and easy breathing by blocking leukotrienes.
How soon can the effect of Monas OFT 4 mg Flash Tablet be observed?
The effect of Monas OFT 4 mg Flash Tablet can be observed after 1-3 hours of administration. Monas OFT 4 mg Flash Tablet is not a fast-acting rescue medicine for asthma attacks and needs to be taken daily to work properly.
How long does the effect of Monas OFT 4 mg Flash Tablet last?
The effect of Monas OFT 4 mg Flash Tablet lasts for an average duration of 24 hours.
Should I use Monas OFT 4 mg Flash Tablet empty stomach?
Monas OFT 4 mg Flash Tablet may be taken with or without food as prescribed by your doctor.
What if I miss a dose of Monas OFT 4 mg Flash Tablet?
If you miss a dose, you may take it as soon as possible. But if it is almost time for your next dose, just skip that dose. Do not double up on doses.
Are there any pregnancy warnings for Monas OFT 4 mg Flash Tablet?
Use of Monas OFT 4 mg Flash Tablet in pregnant women should be avoided unless clearly needed.
General Instructions
- Take Monas OFT 4 mg Flash Tablet exactly as prescribed by your doctor.
- Do not change your Monas OFT 4 mg Flash Tablet dose or stop using asthma medication without your doctor's advice.
- Monas OFT 4 mg Flash Tablet is not a fast-acting rescue medicine for asthma attacks. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working.
- Avoid situations or activities that may trigger an asthma attack.
- Talk to your doctor before using Monas OFT 4 mg Flash Tablet if you're pregnant or breastfeeding. They can help you decide if it's the right choice for you.
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